Therapeutic monitoring of aripiprazole by HPLC with column-switching and spectrophotometric detection.

ischemic stroke is the clinical manifestation of a variety of causes, including thromboembolism, large-vessel arterio-sclerosis, or microangiopathy (17). All of these types of stroke differ in their conventional risk profiles. Genetic variations of single risk factors do not significantly influence the overall risk for ischemic stroke. The impact of a single polymorphism on a complex disease such as an ischemic cerebrovascular event may be influenced by patient selection, ethnic background, or sample size, among others. Our collective represents a cross-sectional sample of survivors of cerebrovascular events. Patients who died within 24 h were not included in our study; our findings therefore can be applied only to the survivors of an acute cerebrovascular event. We conclude that, in contrast to MI, the CYP2C9*2 and CYP2C9*3 alleles do not represent risk factors for ischemic stroke. Endothelial nitric oxide synthase gene interactions and the risk of ischaemic stroke. Nifedipine increases cytochrome P4502C expression and endothelium-derived hyperpolarizing factor-mediated responses in coronary arteries. Comparative studies on the catalytic roles of cytochrome P450 2C9 and its Cys-and Leu-variants in the oxidation of warfarin, flurbiprofen, and diclofe-nac by human liver microsomes. RP, et al. Endothelium-derived hyperpolarizing factor synthase (cytochrome P450 2C9) is a functionally significant source of reactive oxygen species in coronary arteries. Aripiprazole is a novel atypical antipsychotic drug for the treatment of schizophrenia and schizoaffective disorders (1–3). The drug is metabolized by the cytochrome P450 isoenzymes 3A4 and 2D6 (4). Because of high interindi-Table 1. Clinical characteristics, vascular etiology, and CYP2C9 genotype of patients and healthy controls from the Vienna Stroke Registry.